2026 Week 4 College Football Spreads: Four Marquee Games on Tap

Week 4 of the college football season centers the sport's two premier powerhouses: the SEC and the Big Ten.

There are four major matchups in the SEC, highlighted by Texas at Tennessee, with Oklahoma at Georgia, Ole Miss at Florida and Texas A&M at LSU rounding out the quartet

Meanwhile, the Big Ten answers with its own heavy-hitting matchups, including Iowa at Michigan and a classic West Coast (ummm...Pac-12) showdown as Oregon visits USC. 

NCAAF Week 4 spreads at BetOnline Sports & Casino are subject to change. Check out this week's spreads here:

Week 4 Football Lines

Thursday, September 24

• Liberty at Coastal Carolina (-1.5)

Friday, September 25

• Army at Temple (+3)

• Navy at UAB (+10.5)

• Northwestern at Indiana (-22.5)

• Clemson at California (+1.5)

Saturday, September 26

• Houston at Georgia Southern (+19)

• Boise State at Western Michigan (+7.5)

• Texas at Tennessee (+4.5)

• Illinois at Ohio State (-27.5)

• Sam Houston at Texas Tech (-36.5)

• Wake Forest at Louisville (-13.5)

• Colorado at Baylor (-7.5)

• Virginia Tech at Boston College (+14)

• San Diego State at Toledo (-2.5)

• Colorado State at UTSA (-12.5)

• UNLV at Akron (+14)

• Ball State at Kent State (-4)

• South Alabama at Kentucky (-20.5)

• UCLA at Maryland (+2.5)

• Notre Dame at Purdue (+27.5)

• Northern Illinois at Georgia State (-9.5)

• Hawai'i at Wyoming (+3.5)

• Oklahoma at Georgia (-13.5)

• Ole Miss at Florida (-2.5)

• Utah at Iowa State (+11)

• Iowa at Michigan (-5.5)

• TCU at UCF (+3)

• UConn at Miami-Ohio (-5)

• New Mexico at New Mexico State (+13.5)

• Vanderbilt at Auburn (-9)

• Wisconsin at Penn State (-10)

• Nebraska at Michigan State (+6.5)

• South Florida at Bowling Green (+16.5)

• Delaware at Virginia (-20.5)

• James Madison at Old Dominion (+4)

• Central Michigan at Miami (-42)

• Louisiana at Charlotte (+14)

• South Carolina at Alabama (-12)

• Kansas State at Cincinnati (+6.5)

• Oklahoma State at West Virginia (-2.5)

• Southern Miss at Tulane (-19)

• Kennesaw State at Arkansas State (-5)

• Middle Tennessee at Jacksonville State (-9)

• Texas A&M at LSU (-8.5)

• Oregon at USC (+2.5)

• Arizona at Washington State (+13)

• Troy at Utah State (-2.5)

• Appalachian State at NC State (-14)

• Missouri at Mississippi State (-3.5)

• Tulsa at Arkansas (-7)

• Florida Atlantic at UL Monroe (+13.5)

• Missouri State at SMU (-34.5)

• Oregon State at UTEP (+12.5)

• Massachusetts at Sacramento State (+6.5)

• Rice at Fresno State (-12.5)

• Georgia Tech at Stanford (+5)

• Air Force at Nevada (+5)

• Minnesota at Washington (-9.5)