Cardinals vs. Saints Betting Preview Week 8

The Cardinals vs. Saints line was coming in at New Orleans -12.5 after opening at -10.5.  Drew Brees will be starting in this game.

TV: 1 p.m. ET, CBS. LINE: Saints -10. O/U: 48

ABOUT THE CARDINALS (3-3-1): Arizona has an injury concern of its own with running back David Johnson, who did not practice Wednesday and Thursday after logging only one carry Sunday, but backup Chase Edmonds carved up the New York Giants for 126 yards and three touchdowns. Murray threw for a season-low 104 yards against the Giants but he had three touchdown passes against Atlanta in Week 6 and is always a threat with his legs, rushing for 266 yards. "This guy is unique," Payton said. "He is hard to pin down. He has an extremely talented arm. He can get the ball down the field." The Cardinals have a formidable pass rush, ranking third with 22.0 sacks.

ABOUT THE SAINTS (6-1): With a bye following this week's matchup, Payton could elect to play it safe with Brees and stick with Bridgewater, who has put up somewhat modest numbers but has nine touchdown passes against only two interceptions. New Orleans also could get a boost with the expected return of top running back Alvin Kamara, who has rushed for 373 yards and is second on the team with 33 receptions despite missing last week's 36-25 victory at Chicago. Whoever starts at quarterback will be targeting wideout Michael Thomas, who leads the league in both receptions (62) and yards (763). The Saints' defense ranks sixth overall, permitting an average of 327.9 yards.