Opening Betting Lines for 2025 Week 6 NCAA College Football

Alabama, Ole Miss and Oregon came away with massive victories in Week 5. 

The latter two are idle this week, and Bama faces the surprisingly undefeated Vanderbilt Commadores in Tuscaloosa.

The top matchup this week is Miami at Florida State. Miami put a beatdown on FSU last year (36-14), and, of course, the Noles suffered an ugly defeat at Virginia on Friday. 

Below are the opening lines for Week 6, courtesy of BetOnline.ag.

College football Week 6 lines are subject to change.

Week 6 College Football Lines 

Thursday, October 2, 2025 

• Sam Houston at New Mexico State (+1.5) 

Friday, October 3, 2025 

• Western Kentucky at Delaware (-2) 

• Charlotte at South Florida (-27) 

• New Mexico at San Jose State (-3) 

• West Virginia at BYU (-19.5) 

• Colorado State at San Diego State (-6) 

Saturday, October 4, 2025 

• Kentucky at Georgia (-20.5) 

• Iowa State at Cincinnati (PK) 

• Wisconsin at Michigan (-16) 

• Illinois at Purdue (+10) 

• Boston College at Pittsburgh (-6) 

• Clemson at North Carolina (+13) 

• Kansas State at Baylor (-6) 

• Air Force at Navy (-10) 

• Army at UAB (+7.5) 

• Ohio at Ball State (+16.5) 

• Wake Forest at Virginia Tech (-4.5) 

• UTSA at Temple (+6) 

• Oklahoma State at Arizona (-20) 

• Western Michigan at Massachusetts (+12.5) 

• Penn State at UCLA (+25.5) 

• Texas at Florida (+6.5) 

• Vanderbilt at Alabama (-13) 

• Boise State at Notre Dame (-17.5) 

• Washington at Maryland (+4) 

• UL Monroe at Northwestern (-12.5) 

• Oregon State at Appalachian State (+2.5) 

• Virginia at Louisville (-6) 

• Syracuse at SMU (-14.5) 

• Florida International at UConn (-10) 

• James Madison at Georgia State (+20.5) 

• Central Michigan at Akron (+6.5) 

• Eastern Michigan at Buffalo (-9) 

• Miami (OH) at Northern Illinois (+3.5) 

• Kent State at Oklahoma (-45) 

• Michigan State at Nebraska (-11) 

• Texas State at Arkansas State (+11) 

• Coastal Carolina at Old Dominion (-17.5) 

• Texas Tech at Houston (+10.5) 

• UNLV at Wyoming (+4.5) 

• South Alabama at Troy (-3) 

• Florida Atlantic at Rice (-4) 

• Minnesota at Ohio State (-24.5) 

• Miami at Florida State (+4.5) 

• Mississippi State at Texas A&M (-14) 

• Colorado at TCU (-14.5) 

• Kansas at UCF (+4) 

• Tulsa at Memphis (-20.5) 

• Duke at California (+2.5) 

• Nevada at Fresno State (-13.5)