49ers-Giants Daily Fantasy NFL Picks, Betting Odds

Submitted by Dan Shapiro on

Written by :

Dan Shapiro

Published on :

Gambling911.com has your 49ers-Giants Daily Fantasy NFL picks along with the latest betting odds that had New York as a -6.5 home favorite.

What to Consider With The 49ers: Because the 49ers rank among the bottom ten in terms of the pass and the run, Eli Manning is in play.

What to Consider With The Giants: The running back situation is in flux with a constant rotation between three, none of whom are yet to stand out.  Even against one of the weakest teams against the run, New York is really not an option here.

Who to Play: Eli Manning ($6.8K) – He’ll go up against a week pass defense here.  Manning is definitely in play.  Through four games, Manning is on pace for a 28:4 TD:INT ratio.

- Dan Shapiro, Gambling911.com

Related Content

Browns Trade Myles Garrett to Rams and Books Quick to React

Browns Trade Myles Garrett to Rams and Books Quick to React

Myles Garrett is heading to LA in exchange for two-time Pro Bowl pass rusher Jared Verse and multiple draft picks....and just like that, the Rams are Super Bowl favorites.
Green Bay Packers Josh Jacobs Arrested for Domestic Violence: Doesn't Bode Well for Packers 2026 Odds

Green Bay Packers Josh Jacobs Arrested for Domestic Violence: Doesn't Bode Well for Packers 2026 Odds

Green Bay Packers star running back Josh Jacobs was arrested Tuesday and booked on several domestic violence charges, according to the Hobart-Lawrence (Wisconsin) Police Department.
Bo Nix Broncos

Denver Broncos Spreads for All 2026 Regular Season Games

Remarkably, the Broncos still are listed as underdogs in seven games early on for the upcoming season, including five of the first six games. If they can start the season hot, we will have some idea where the Broncos are heading pretty quickly.
Aaron Rodgers Steelers

Bet on Will Aaron Rodgers be Benched By Steelers During 2026 Regular Season?

Aaron Rodgers announced earlier Wednesday that the upcoming season will be his last.