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Gambling911.com has your Giants-Bills Daily Fantasy NFL picks along with the latest betting line set at Buffalo -5.
What to Consider With the Giants: The Giants have allowed the eighth-most points to opposing backs so far this year.
What to Consider With the Bills: Buffalo is solid against the pass, ranking 8th in the league. Likewise, Buffalo has been effective against opposing running backs.
Who to Play: LeSean McCoy is likely to sit this one out so Karlos Williams ($3.4K) is an excellent option at running back at a very decent price. The Giants have not had much success against opposing running backs as noted above.
Williams rushed 12 times for 110 yards and a touchdown in Buffalo's Week 3 win over the Dolphins.
Mary Montgomery, Gambling911.com
