Virginia Tech arrives chasing a win to secure bowl eligibility, while Duke can reach the eight-win mark for the third consecutive season — which has happened only once before in program history.
The Aggies are still in the hunt for their first Southeastern Conference championship and playoff berth but can ill afford another loss on either count.
Missouri sits just outside the AP Top 25 and looks to rebound from last week's 34-30 loss at South Carolina that dropped the Tigers to midpack in the conference