Wake Forest vs. Clemson Betting Line at Tigers -21.5

The Wake Forest vs. Clemson game is all about whether the Tigers can cover a -21.5 line against a team that is, well, has just one loss heading into Week 6.

"I would say that watching them on film, they are playing as well as any team in the country," Wake Forest head coach Dave Clawson said. "Every year I look at depth charts. I looked at Clemson last year and thought, 'This kid is graduating and this one will leave early. OK, maybe next year is the year that they take a little bit of a dip.'

As an underdog of 21.5 to 31 points, Wake Forest has gone 4-0 Against The Spread over the last three seasons.  This is a pretty good Demon Deacons team with a 3-1 Straight Up and ATS record so far this season.

Clemson has gone 2-4 Against The Spread over the past three seasons as a favorite of 21.5 to 31 points.

- Mary Montgomery, Gambling911.com