MLB Betting Analysis - September 16, 2025

Written by:
C Costigan
Published on:
Sep/16/2025

Gambling911.com looks at potential value in MLB betting lines and totals based on a number of factors for games played Tuesday September 16, 2025.

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Tuesday September 16

The Guardians are 10-2 and the line here favors Detroit.  The public loves the Tigers too, though the line is dropping for whatever reason. 

Cleveland Guardians career statistics vs. Casey Mize are 11 for 28 (.289). 

Mize pitched well in his last start with a victory over the Yankees, surrendering just two runs on four hits over six strong frames. 

From Winners and Whiners

"The standings show Detroit’s strength, especially at home. They are pushing for the American League title while also securing the division. But they have struggled recently as they were almost swept by the Marlins in their previous series. They have lost seven of their last 12 games, and they have just a 4-3 record versus Cleveland. The Guardians are on a heater as they have won nine of their last 10 games. It’s a sustained winning streak as well. They have won 14 of their last 19 games and they are starting Joey Cantillo, who has looked great recently. He has a 2.52 ERA since the All-Star break. The Tigers are starting Casey Mize and his 3.47 ERA during home games. He also has a 5.23 ERA in the second half of the calendar. Offensive chances will be few and far between, but Cleveland’s bullpen and its momentum will be hard to stop."

Take the Guardians here at +122

Current Hottest Teams in Order:

  • Seattle Mariners
  • Cleveland Guardians
  • Philadelphia Phillies 
  • Toronto Blue Jays 
  • Texas Rangers
  • New York Yankees

Current Worst Teams in Order: 

  • Colorado Rockies
  • New York Mets
  • Pittsburgh Pirates
  • LA Angels
  • Minnesota Twins
  • Tampa Bay Rays
  • Houston Astros
  • Atlanta Braves
  • Cincinnati Reds
  • St. Louis Cardinals

Monday September 15

Current Hottest Teams in Order:

  • Seattle Mariners
  • Cleveland Guardians
  • Philadelphia Phillies 
  • Toronto Blue Jays 
  • Texas Rangers
  • New York Yankees

Current Worst Teams in Order: 

  • Colorado Rockies
  • New York Mets
  • Pittsburgh Pirates
  • LA Angels
  • Minnesota Twins
  • Tampa Bay Rays
  • Houston Astros
  • Atlanta Braves
  • Cincinnati Reds
  • St. Louis Cardinals

Phillies @ Dodgers - Heavy action was on the Phillies in LA Monday night, which could explain the line move from Dodgers -145 to -116. 

Cubs @ Pirates 

From ESPN

Jameson Taillon missed a couple of turns with a groin injury. The Chicago Cubs limited him to only 79 pitches in his first game off the IL, but he should be able to handle a normal workload on the road against the Pittsburgh Pirates. Taillon generally doesn't rack up a bunch of strikeouts, but he's recorded at least six frames in 11 of his 20 outings, and outs are integral to points league scoring. The Pirates are the least potent team in the league facing righties.

The line dropped from Cubs -130 to -112. 

Pittsburgh Pirates career statistics vs. Jameson Taillon are 26-for-96 hitting (.276). 

Taillon allowed six hits and two runs with two walks and two strikeouts over 4 1/3 innings in a no-decision against the Braves on Wednesday. 

Chicago Cubs career statistics vs. Braxton Ashcraft are just 3-for-21. 

8 of the last 9 in this series have seen seven or fewer runs. 

The total has moved from 8.5 to 8. 

Take the Under 8 Cubs/Pirates

Friday September 12 

Here are your hot streaking MLB teams at the moment: 

  • Boston Red Sox
  • Tampa Bay Rays 
  • Cleveland Guardians 
  • Chicago White Sox
  • Texas Rangers
  • Philadelphia Phillies
  • St. Louis Cardinals 
  • Milwaukee Brewers 
  • San Francisco Giants
  • Cincinnati Reds 

Teams to avoid at the moment that were looking decent at one point: 

  • Minnesota Twins
  • Kansas City Royals
  • Houston Astros
  • Athletics 
  • Seattle Mariners
  • New York Mets
  • Miami Marlins 
  • Milwaukee Brewers 
  • LA Dodgers
  • San Diego Padres  

Series Edge

  • Yankees vs. Red Sox (Red Sox 8-1)
  • White Sox vs. Guardians (Guardians 8-2) 

Royals @ Phillies

A few top cappers are on the Over here. 93% of the betting public that's on this total agree, and the number has not moved off the 9. 

Philadelphia Phillies career statistics vs. Michael Lorenzen is 16-for-59 (.271) 

Kansas City Royals career statistics vs. Walker Buehler is just 12-for-55 (.218) 

Lorenzen gave up four runs in 5 1/3 innings Sunday in a loss to the Twins.

The last six in this series have gone Over this total. 

Take the Over 9 here

Gambling911.com Free Picks Record (53-47-2)

September 16 - Cleveland Guardians vs. Detroit Tigers - Guardians +122 ()
September 15 - Chicago Cubs vs. Pittsburgh Pirates - Under 8 (WIN)
September 15 - Atlanta Falcons vs. Minnesota Vikings - Falcons +3.5 (LOSS) 
September 15 - Buffalo Bills vs. New York Jets - Jets +6.5 (LOSS)
September 14 - Seattle Seahawks vs. Pittsburgh Steelers - Steelers -3 ()
September 13 - Texas A&M Aggies vs. Notre Dame Fighting Irish - Notre Dame -6.5 (LOSS)
September 13 - Florida Gators vs. LSU Tigers - Florida +7.5 (LOSS)
September 13 - Clemson Tigers vs. Georgia Tech Yellow Jackets - Georgia Tech +3 (WIN)
September 12 - Kansas City Royals vs. Philadelphia Phillies - Over 9 (WIN)
September 11 - Washington Commanders vs. Green Bay Packers - Commanders +3.5 (LOSS)
September 10 - No Picks Today
September 9 - Chicago Cubs vs. Atlanta Braves - Under 8.5 (WIN)
September 8 - Boston Red Sox vs. Athletics - Red Sox -160 (WIN)
September 8 - Milwaukee Brewers vs. Texas Rangers - Brewers (LOSS)
September 7 - Pittsburgh Steelers vs. New York Jets - Steelers -2.5 (LOSS)
September 6 - Illinois vs. Duke - Duke -2.5 (LOSS)
September 6 - Baylor Bears vs. SMU Mustangs - SMU -2.5 (LOSS) 
September 6 - Virginia Cavaliers vs. NC State - NC State -2.5 (WIN)
September 5 - Kansas City Chiefs vs. LA Chargers - Chiefs -3 (LOSS)
September 4 - Cleveland Guardians vs. Tampa Bay Rays - Rays -160 (WIN)
September 3 - Atlanta Braves vs. Chicago Cubs - Under 8.5 (WIN)
September 2 - Athletics vs. St. Louis Cardinals - Athletics -107 (LOSS)
September 2 - LA Dodgers vs. Pittsburgh Pirates -165 - Dodgers -165 (LOSS)
September 1 - Philadelphia Phillies vs. Milwaukee Brewers - Under 9 (LOSS)
August 31 - Atlanta Braves vs. Philadelphia Phillies - Phillies -161 (LOSS)
August 30 - Texas Longhorns vs. Ohio State Buckeyes - Buckeyes PICK'EM (WIN)
August 29 - Auburn Tigers vs. Baylor Bayors - Auburn Tigers -2.5 (WIN)
August 29 - Miami Marlins vs. New York Mets - Under 7.5 (LOSS)
August 28 - No Picks 
August 27 - Boston Red Sox vs. Baltimore Orioles - Under 9 (WIN)
August 26 - No Picks 
August 25 - Tampa Bay Rays vs. Cleveland Guardians - Under 7.5 (WIN)
August 24 - No Picks
August 23 - Iowa State vs. Kansas State - Kansas State -3 (LOSS)
August 21 - Boston Red Sox vs. New York Yankees - Yankees -142 (LOSS)
August 20 - Seattle Mariners vs. Philadelphia Phillies - Over 8.5 (WIN)
August 19 - Toronto Blue Jays vs. Pittsburgh Pirates - Under 7.5 (LOSS)
August 17 - No Picks 
August 16 - Texas Rangers vs. Toronto Blue Jays - Blue Jays -165 (WIN)
August 16 - Miami Marlins vs. Boston Red Sox - Under 9.5 (LOSS)
August 15 - - No Picks 
August 14 - Chicago Cubs vs. Toronto Blue Jays - Blue Jays -103 (WIN)
August 13 - No Picks 
August 12 - No Picks 
August 11 - San Diego Padres vs. San Francisco Giants - Under 7 (WIN)
August 10 - Cleveland Guardians vs. Chicago White Sox - Guardians -122 (LOSS)
August 10 - New York Mets vs. Milwaukee Brewers - Under 8 (LOSS)
August 9 - Kansas City Royals vs. Minnesota Twins - Under 8.5 (WIN)
August 8 - Phillies vs. Rangers - Under 7 (LOSS)
August 8 - Cincinnati Reds vs. Pittsburgh Pirates - Reds -118 (LOSS)
August 7 - No Picks
August 6 - No Picks 
August 5 - St. Louis Cardinals vs. LA Dodgers - Over 9 (WIN)
August 5 - Athletics vs. Washington Nationals - Athletics +112 (WIN)
August 5 - Athletics vs. Washington Nationals - Over 8.5 (WIN)
August 4 - San Diego Padres vs. Arizona Diamondbacks -125 (LOSS)
August 3 - New York Yankees vs. Miami Marlins - Marlins +103 (WIN)
August 2 - LA Dodgers vs. Tampa Bay Rays - Rays +104 (WIN)
August 1 - Houston Astros vs. Boston Red Sox - Over 8 (LOSS)
July 30 - Toronto Blue Jays vs. Baltimore Orioles - Over 9.5 (WIN)
July 30 - Toronto Blue Jays vs. Baltimore Orioles - Blue Jays +103 (WIN)
July 29 - No Picks
July 28 - Chicago Cubs vs. Milwaukee Brewers Under 8 (LOSS)
July 28 - Toronto Blue Jays vs. Baltimore Orioles Over 9.5 (WIN)
July 27 - No Picks Today 
July 26 - No Picks Today 
July 25 - LA Dodgers vs. Boston Red Sox - Red Sox -102 (LOSS)
July 24 - Toronto Blue Jays vs. Detroit Tigers - Tigers -130 (LOSS)
July 23 - Boston Red Sox vs. Philadelphia Phillies - Red Sox +146 (WIN)
July 22 - No Picks Today 
July 21 - San Francisco Giants vs. Atlanta Braves - Giants +118 (LOSS)
July 20 - Detroit Tigers vs. Texas Rangers - Under 7 (WIN)
July 19 - New York Yankees vs. Atlanta Braves - Braves +112 (LOSS)
July 18 - No Picks Today
July 13 - Tampa Bay Rays vs. Boston Red Sox - Red Sox -115 (WIN)
July 12 - No Picks Today
July 11 - Texas Rangers vs. Houston Astros - Rangers +108 (WIN) 
July 10 - No Picks Today 
July 9 - Miami Marlins vs. Cincinnati Reds - Reds -136 (WIN)
July 8 - No Picks Today
July 7 - Cleveland Guardians vs. Houston Astros - Guardians +118 (WIN)
July 6 - St. Louis Cardinals vs. Chicago Cubs - Under 7.5 (LOSS)
July 5 - Athletics vs. San Francisco Giants - Under 9 (PUSH)
July 4 - St. Louis Cardinals vs. Chicago Cubs - Under 9.5 (LOSS)
July 3 - No Picks Today
July 2 - No Picks Today 
July 1 - Baltimore Orioles vs. Texas Rangers - Under 7.5(LOSS)
June 29 - Philadelphia Phillies vs. Atlanta Braves - Braves -157 (LOSS)
June 28 - Miami Marlins vs. Arizona Diamondbacks - Marlins +136 (WIN)
June 27 - Athletics vs. New York Yankees - Under 8.5 (WIN)
June 26 - Toronto Blue Jays vs. Cleveland Guardians - Guardians -130 (LOSS)
June 26 - Seattle Mariners vs. Minnesota Twins - Under 8.5 (LOSS)
June 24 - Tampa Bay Rays vs. Kansas City Royals - Under 8.5 (WIN)
June 22 - Cleveland Guardians vs. Athletics - Athletics +105 (LOSS)
June 22 - Indiana Pacers vs. Oklahoma City Thunder - Under 215 (WIN)
June 21 - Chicago White Sox vs. Toronto Blue Jays Under 8.5 (WIN)
June 19 - Philadelphia Phillies vs. Miami Marlins - Under 8 (WIN)
June 18 - Philadelphia Phillies vs. Miami Marlins - Miami Marlins +146 (LOSS)
June 17 - No Picks Today
June 16 - Indiana Pacers vs. Oklahoma City Thunder - Oklahoma City Thunder -9.5(WIN)
June 15 - Toronto Blue Jays vs. Philadelphia Phillies - Toronto Blue Jays +143 (LOSS)
June 15 - Miami Marlins vs. Washington Nationals - Under 7.5 (WIN)
June 14 - Toronto Blue Jays vs. Philadelphia Phillies - Toronto Blue Jays +140 (LOSS)
June 13 - Colorado Rockies vs. Atlanta Braves - Under 8.5 (LOSS)
June 12 - No Picks Today
June 11 - No Picks Today
June 10 - Miami Marlins vs. Pittsburgh Pirates - Under 8 (WIN)
June 8 - LA Dodgers vs. St. Louis Cardinals - St. Louis Cardinals +108 (LOSS)
June 7 - Philadelphia Phillies vs. Pittsburgh Pirates - Pittsburgh Pirates +124 (WIN)
June 6 - Kansas City Royals vs. Chicago White Sox - Chicago White Sox +160 (WIN)
June 4 - Baltimore Orioles vs. Seattle Mariners - Baltimore Orioles Even (WIN)
June 2 - Colorado Rockies vs. Miami Marlins - Under 8 (LOSS)
June 1 - Tampa Bay Rays vs. Houston Astros - Tampa Bay Rays +144 (LOSS)
May 30 - Colorado Rockies vs. New York Mets - Under 8 (WIN)
May 29 - Tampa Bay Rays vs. Houston Astros - Under 8 (LOSS)
May 26 - Colorado Rockies vs. Chicago Cubs - Under 8 (WIN)
May 25 - Miami Marlins vs. LA Angels - Miami Marlins +117 (WIN)
May 24 - Milwaukee Brewers vs. Pittsburgh Pirates - Under 9 (WIN)
May 16 - Boston Celtics vs. New York Knicks - Boston Celtics +2.5 (LOSS)
May 13 - Denver Nuggets vs. Oklahoma City Thunder - Oklahoma City Thunder -10 (LOSS)
May 8 - LA Dodgers vs. Arizona Diamondbacks Under 9 (WIN)
May 7 - New York Knicks vs. Boston Celtics - New York Knicks +10.5 (WIN)
May 1 - Denver Nuggets vs. LA Clippers - LA Clippers -6 (PUSH)
April 29 - Milwaukee Bucks vs. Indiana Pacers - Milwaukee Bucks +8 (WIN)
April 25 - LA Lakers vs. Minnesota Timberwolves - Minnesota Timberwolves -3.5 (WIN)
April 19 - Minnesota Timberwolves vs. LA Lakers - Minnesota Timberwolves +4.5 (WIN)
April 6 - New York Yankees vs. Pittsburgh Pirates - Pittsburgh Pirates +138 (WIN)
April 5 - Houston Cougars vs. Duke Blue Devils - Houston Cougars +5 (WIN)

- Ean Lamb, Gambling911.com 

 

- Ean Lamb, Gambling911.com

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