2025 Week 4 Betting Lines

Submitted by C Costigan on

Written by :

C Costigan

Published on :

Three blocked field goal attempts in the final two minutes of three early-afternoon games kicked off a crazy Week 3 in the National Football League.

And then we witnessed a menagerie of blocked kicks throughout the day!

It was an exciting week as many outcomes were decided in the last minute of the game.

What will be in store for Week 4. Below are the 2025 Week 4 NFL opening lines, and if there’s a big movement from the look-ahead numbers, that will be notated.

NFL Week 4 spreads are subject to change.

BetOnline Sportsbook – NCAA Football Welcome Bonus

NFL Week 4 Lines

 

Thursday, September 25, 2025

 

  • Seattle Seahawks at Arizona Cardinals (-1.5)
    • Lookahead line was –2.5

Sunday, September 28, 2025

 

  • Minnesota Vikings (-1.5) at Pittsburgh Steelers
    • Look-ahead line was Steelers -1.

 

  • Washington Commanders (-3) at Atlanta Falcons
    • Look-ahead line was -1.

 

  • New Orleans Saints at Buffalo Bills (-16.5)
    • Look-ahead line was –15.5

 

  • Philadelphia Eagles (-3) at Tampa Bay Buccaneers

 

  • Carolina Panthers at New England Patriots (-4)
    • Look-ahead line was –5.5

 

  • Cleveland Browns at Detroit Lions (-8.5)
    • Look-ahead line was -10.

 

  • Tennessee Titans at Houston Texans (-7)

 

  • Los Angeles Chargers (-6) at New York Giants

 

  • Jacksonville Jaguars at San Francisco 49ers (-3.5)

 

  • Indianapolis Colts at Los Angeles Rams (-4)
    • Look-ahead line was -5.

 

  • Chicago Bears at Las Vegas Raiders (-1.5)
    • Look-ahead line was -2.5.

 

  • Baltimore Ravens (-3) at Kansas City Chiefs

 

  • Green Bay Packers (-6) at Dallas Cowboys
    • Look-ahead line was -5.

Monday, September 29, 2025

 

  • New York Jets at Miami Dolphins (-2.5)

 

  • Cincinnati Bengals at Denver Broncos (-7.5)
    • Look-ahead line was -6.5.

Related Content

Gambling911.com news

Live Gambling News, Top Trending: Updates 24/7 - Wednesday April 22, 2026

Live News: - Dwight Manley - MGM - Spiked Drink Suit - Virginia Redistricting - Coinbase - Gemini - Capital Bra - NBA Playoffs - Reno News - Tamarack Casino Robbery - Howard Lutnick
Denzel Boston

What Are Denzel Boston NFL Draft Position Odds Over, Under?

Denzel Boston had an over/under of 26.5 Draft position coming into Thursday
Chris Johnson

What Are Chris Johnson NFL Draft Position Odds Over, Under?

Chris Johnson was coming in with an over/under pick position of 31.5 for Thursday's NFL Draft.
Prediction Markets

Three US Senators Introduce Predictoin Market Legislation Defining Sites as Gambling

Senators are looking to prohibit certain event contracts involving sports and casino style games