Chiefs vs. 49ers Betting Preview October 20

The Chiefs vs. 49ers line had San Francisco as the -1 home favorite. Sagarin suggests the Chiefs should be the favorite here.

Kansas City is looking to remain undefeated.  They are 4-1 Against The Spread.  The 49ers, meanwhile, are just 3-3 Straight Up and Against The Spread.

Patrick Mahomes threw for a bunch of yards. Travis Kelce caught a whole lot of his passes. And Kareem Hunt plowed into the end zone once again, sending a torrent of red fireworks flying over Arrowhead Stadium on Monday night.

It might as well have been six years ago, the last time that trio of Chiefs played in a home game together.

But with injuries having ravaged their offense, the Chiefs were forced to lean on two of their stalwarts and the return of their erstwhile star running back to beat the Saints, 26-13. Mahomes finished with 331 yards through the air, Kelce had a game-high nine catches for 70 yards, and Hunt ran 27 times for 102 yards and a touchdown.

Brock Purdy threw for 255 yards and three touchdowns, and the Niners never trailed in a 36-24 victory over the Seattle Seahawks on Thursday night.

Deebo Samuel had a 76-yard catch-and-run touchdown and finished with three catches for 102 yards for the defending NFC champions (3-3), who moved into a tie with Seattle (3-3) for first place in the NFC West after an uneven start to the season.

George Kittle added five receptions for 58 yards and two scores for the 49ers, who beat the Seahawks for a sixth straight time. Kyle Juszczyk had a late TD run, and he and Kittle both celebrated their scores by leaping into the stands to embrace their wives, who were sitting together in the first row.