49ers-Giants Daily Fantasy NFL Picks, Betting Odds

Submitted by Dan Shapiro on

Written by :

Dan Shapiro

Published on :

Gambling911.com has your 49ers-Giants Daily Fantasy NFL picks along with the latest betting odds that had New York as a -6.5 home favorite.

What to Consider With The 49ers: Because the 49ers rank among the bottom ten in terms of the pass and the run, Eli Manning is in play.

What to Consider With The Giants: The running back situation is in flux with a constant rotation between three, none of whom are yet to stand out.  Even against one of the weakest teams against the run, New York is really not an option here.

Who to Play: Eli Manning ($6.8K) – He’ll go up against a week pass defense here.  Manning is definitely in play.  Through four games, Manning is on pace for a 28:4 TD:INT ratio.

- Dan Shapiro, Gambling911.com

Related Content

Browns vs. Steelers PPH Sportsbook Prop Bets - Thursday Night Football

Browns vs. Steelers PPH Sportsbook Prop Bets - Thursday Night Football

While Gambling911.com has been bullish on the Browns over the past two weeks, action was balanced on this one with the line only moving up a half point over the course of the week, making this game less attractive in terms of a glaring "must bet" situation.
Updated 2027 Super Bowl Odds After Week 3

Updated 2027 Super Bowl Odds After Week 3

The Buffalo Bills have now overtaken the LA Rams as the Super Bowl favorites.
Oddsmakers Now Make Tampa Bay Bucs Todd Bowles -120 Favorite to be First NFL Head Coach Fired

Oddsmakers Now Make Tampa Bay Bucs Todd Bowles -120 Favorite to be First NFL Head Coach Fired

Green Bay Packers head coach Matt LaFleur now has the second shortest odds.
Bet on When Will J.J. McCarthy Make His First Start in 2026

Bet on When Will J.J. McCarthy Make His First Start in 2026

Apparently, John Harbaugh trusts his brother Jim’s evaluation more than NFL tape.