Chiefs vs 49ers Predictions, Prop Bets October 23

Submitted by Tyrone Black on

Written by :

Tyrone Black

Published on :

Chiefs vs 49ers Predictions, Prop Bets

The Kansas City Chiefs are coming off a close loss to the Buffalo Bills. The San Francisco 49ers suffered a tough loss in Atlanta and will be happy to be back home. When 2 Super Bowl contenders meet up, should you look to the side or the total to find the winning NFL pick?

2-footballisback-300x250.gif

The line on this game was coming in at Chiefs -2.5 after being as high as -3.  A few books had moved to -2 on Friday.  The news of the Christian McCaffrey trade to the 49ers appears to have had little impact on this week's game line, at least so far.

The trend for favorites of -2.5 covering in 10 out of 11 games had cooled off last week. 

We get a number of 2.36, indicating an accurate betting line here. 

A comparable game would be Baltimore -2.5/-3 vs. New England whereby the road favorite Baltimore covered with a 11 point win.  The line on this one was on the money as well. 

BetUS host TJ Rives, and expert handicappers Scot Kellen and Chris Farley analyze the NFL game Kansas City Chiefs vs San Francisco 49ers. They'll go over the latest football betting trends, and best value NFL odds available and share their football picks and expert predictions for this NFL Week 7 game.

Chiefs vs. 49ers Prop Bets

Rot     Player to Score First Touchdown in The Game     Moneyline
101     Travis Kelce (KC)         +650
102     Clyde Edwards-Helaire (KC)         +700
103     Jerick McKinnon (KC)         +1100
104     Juju Smith-Schuster (KC)         +1200
105     Marquez Valdes-Scantling (KC)         +1600
106     Isiah Pacheco (KC)         +1800
107     Patrick Mahomes (KC)         +2000
108     Mecole Hardman (KC)         +2200
109     Jody Fortson (KC)         +2800
110     Justin Watson (KC)         +3300
111     Noah Gray (KC)         +4000
112     Skyy Moore (KC)         +4000
113     Deebo Samuel (SF)         +700
114     Jeff Wilson (SF)         +750
115     Brandon Aiyuk (SF)         +1200
116     George Kittle (SF)         +1200
117     Tevin Coleman (SF)         +1600
118     Jauan Jennings (SF)         +2000
119     Kyle Juszczyk (SF)         +3300
120     Ross Dwelley (SF)         +3300
121     Charlie Woerner (SF)         +5000
122     Jimmy Garoppolo (SF)         +5000
123     Tyrion Davis-Price (SF)         +5000
124     Ray-Ray McCloud (SF)         +6600
125     Any Other Touchdown Scorer         +700
126     No Touchdown Scorer         +10000
Rot     Patrick Mahomes (KC) Total Passing Yards     Moneyline
1001     Over  290½  Passing Yards     Ev
1002     Under  290½  Passing Yards     -130
Must Start for action.
Rot     Patrick Mahomes (KC) Total Touchdown Passes     Moneyline
1007     Over  2½  TD Passes     +150
1008     Under  2½  TD Passes     -180
Must Start for action.
Rot     Patrick Mahomes (KC) Total Interceptions     Moneyline
1011     Over  ½  Interceptions     -105
1012     Under  ½  Interceptions     -125
Rot     Clyde Edwards-Helaire (KC) Total Rushing Attempts     Moneyline
1043     Over  9½  Rush Attempts     -115
1044     Under  9½  Rush Attempts     -115
Must Play for action. Must have 1 Rush Attempt for Action.
Rot     Clyde Edwards-Helaire (KC) Longest Rush From Scrimmage     Moneyline
1047     Over  10½  Yards     -115
1048     Under  10½  Yards     -115
Must Play for action. Must have 1 Rush Attempt for Action.
Rot     Clyde Edwards-Helaire (KC) Total Receptions     Moneyline
1049     Over  2½  Receptions     Ev
1050     Under  2½  Receptions     -130
Rot     Winning Margin     Moneyline
3089     Chiefs to win by 1-6 pts         +300
3090     Chiefs to win by 7-12 pts         +500
3091     Chiefs to win by 13-18 pts         +700
3092     Chiefs to win by 19-24 pts         +1200
3093     Chiefs to win by 25-30 pts         +2200
3094     Chiefs to win by 31-36 pts         +3500
3095     Chiefs to win by 37-42 pts         +5000
3096     Chiefs to win by 43 or More pts         +7500
3097     49ers to win by 1-6 pts         +330
3098     49ers to win by 7-12 pts         +600
3099     49ers to win by 13-18 pts         +900
3100     49ers to win by 19-24 pts         +1800
3101     49ers to win by 25-30 pts         +3300
3102     49ers to win by 31-36 pts         +4500
3103     49ers to win by 37-42 pts         +7500
3104     49ers to win by 43 or More pts         +10000
3105     Tie         +5000

- Tyrone Black, Gambling911.com

Related Content

Northwestern vs. Indiana Total Receiving Yards Prop Bets: Charlie Becker, Griffin Wilde, Nick Marsh

Northwestern vs. Indiana Total Receiving Yards Prop Bets: Charlie Becker, Griffin Wilde, Nick Marsh

At 90+ receiving yards, Charlie Becker starts paying better than even odds and all the way up to $1700 for every $100 bet with 175+ receiving yards.
Türkiye v France Betting Odds - Goalscorer Markets: Kylian Mbappe, Ousmane Dembele, Esteban Lepaul

Türkiye v France Betting Odds - Goalscorer Markets: Kylian Mbappe, Ousmane Dembele, Esteban Lepaul

There have been over 2.5 goals scored in Türkiye's last 3 league games while France have scored at least two goals in their last 3 league games, making the goalscorer betting markets for this match quite enticing.
Seminole Classic Casino Hollywood Florida October 2026 Promotions Includes Reduced Baccarat Commission

Seminole Classic Casino Hollywood Florida October 2026 Promotions Includes Reduced Baccarat Commission

The casino will also feature a Baccarat tournament every Friday of during the month of October as well as a Blackjack tournament and Bingo special event.
Santa Rosa California's Graton Casino Hosts Global Debut of Wheel of Fortune Magic Coins

Santa Rosa California's Graton Casino Hosts Global Debut of Wheel of Fortune Magic Coins

The new game is described as a much more feature-heavy video slot than the original Wheel of Fortune machine. IGT is preparing to showcase it at G2E 2026 on the RISE55 cabinet.