49ers vs. Seahawks Betting Preview for Thursday Night Football October 10

49ers vs. Seahawks Betting Preview for Thursday Night Football October 10.

The 2-3 49ers will take on the 3-2 Seahawks in Seattle Thursday night.  San Francisco comes into this game as a -3.5 favorite after having lost three of their last four.  Seattle started the season off 3-0 but has since dropped their last two games.

San Francisco has won the last five games in this series, all by more than a touchdown.

Players to Watch

WR Brandon Aiyuk. After being held to 13 catches for 167 yards in the first four games, Aiyuk broke through in a big way last week with eight catches for 147 yards. Aiyuk has had fewer than 75 yards receiving in six of his past seven games against the Seahawks.

Aiyuk's total receiving yards for this game are coming in at Over/Under 68.5.

Aiyuk had taken something of a backseat to Jauan Jennings across the first four games of the season with his receiving yards high over the first four weeks just 48 yards.

"I haven't watched myself, but definitely felt better for myself today," Aiyuk said about his performance versus the Cardinals last week.

QB Geno Smith has been the biggest offensive bright spot for the Seahawks so far this season, with a league-high 1,466 passing yards, five passing touchdowns and an NFL-best 293.2 yards per game through the air.

His passing yards total was listed at 249.5.

Smith was sacked five times through the first three-and-a-half quarters in the 20-29 loss to the New York Giants last week.

"He's tough as nails, man," first-year offensive coordinator Ryan Grubb said. "He's a total warrior. ... This week, probably more than any week, it would've been very easy for him to let frustration take over his game.

"That's the thing you see from a veteran quarterback is a guy that can still be passionate and be himself and find a way to get himself back to room temperature to make good decisions and still give us a chance to win."

Sagarin gives us a number of 3.75 here favoring San Francisco.  This one is on the money.  Our model does not provide for any advantage either way.