2025 NFL Week 16 Betting Odds

Week 15 of the 2025 NFL season will be remembered for a few things.

First, it will be remembered that arguably the best players on each side of the ball suffered season-ending injuries. Still speculation on Micah Parsons, but non-contact injuries rarely aren’t serious.

We also saw the Chiefs get eliminated from the playoffs for the first time in 11 years, which encompasses every Andy Reid season in Kansas City.

Lastly, it will be remembered for a rotund Philip Rivers coming out of retirement on the week of his 44^th birthday and almost leading the Colts to victory in front of a raucous Seahawks crowd.

On to Week 16, which is highlighted by an awesome Thursday night matchup with the Seattle Seahawks hosting the Los Angeles Rams. There are two other games pitting teams at the top of their division with Chicago hosting Green Bay and Carolina hosting Tampa Bay.

We also have two Saturday games on the docket!

NFL Week 16 spreads are subject to change. 

NFL Week 16

Thursday, December 17

• Los Angeles Rams at Seattle Seahawks (-1)

Saturday, December 20

• Philadelphia Eagles at Washington Commanders (+5½)

• Green Bay Packers at Chicago Bears (+3)

Sunday, December 21

• Buffalo Bills at Cleveland Browns (+10)
  • Lookahead line was Cleveland +9.

• Los Angeles Chargers at Dallas Cowboys (-1½)

• Kansas City Chiefs at Tennessee Titans (+4½)
  • Lookahead line was Tennessee +11½. Mahomes injury moved line seven points.

• Cincinnati Bengals at Miami Dolphins (-1)
  • Lookahead line was a pick’em.

• New York Jets at New Orleans Saints (-4)
  • Lookahead line opened New Orleans -3.

• Minnesota Vikings at New York Giants (+1½)

• Tampa Bay Buccaneers at Carolina Panthers (+2½)

• Jacksonville Jaguars at Denver Broncos (-2½)

• Atlanta Falcons at Arizona Cardinals (+1½)
  • Lookahead line was Arizona -1. We now have a new favorite.

• Pittsburgh Steelers at Detroit Lions (-6½)

• Las Vegas Raiders at Houston Texans (-14)
  • Lookahead line was Houston -12½.

• New England Patriots at Baltimore Ravens (-2½)
  • Lookahead line was Baltimore -1.

• BetOnline Press