Cubs vs. Pirates Betting Pick, DFS Plays – April 21

Submitted by Dan Shapiro on

Written by :

Dan Shapiro

Published on :

Gambling911.com has your Cubs vs. Pirates betting pick and DFS plays for April 21. 

Best Bets: UNDER 7

Best DFS Picks: Francisco Liriano

PITCHING MATCHUP: Cubs LH Travis Wood (1-1, 2.31 ERA) vs. Pirates LH Francisco Liriano (0-1, 2.08 ERA)

Betting Line: Pittsburgh -150, Chicago Cubs +142, Total: 7

Wood is 5-1 with a 2.31 ERA in seven outings (six starts) at PNC Park. He has won his last three decisions in Pittsburgh dating to 2011. 

Liriano is desperately looking for his first win of the season following to quality starts.  The Cubs offer the perfect opportunity. 

He is 4-2 with a 2.30 ERA in nine career starts against them and this new look Chicago team doesn’t affect that edge.  He has only permitted 13 of 70 at bats to the current Cubs roster. 

This does not appear to be a good matchup for daily fantasy players outside of selecting Liriano priced at $8.7K.

- Dan Shapiro, Gambling911.com

Related Content

Pope Leo XIV Chicago White Sox Prop Bets: Will He Attend a Game, Mentions, More

Pope Leo XIV Chicago White Sox Prop Bets: Will He Attend a Game, Mentions, More

The Pope pays out $300 for every $100 bet should he attend one of the White Sox games.
MLB Division Series and Game 1 Odds 2026

MLB Division Series and Game 1 Odds 2026

Three of the four Wild Card series wrapped up in two games, while the Braves and Phillies will play their rubber match this evening to see which team advances to the NLDS.
Seattle Mariners Next Manager Torey Lovullo Odds

Seattle Mariners Next Manager Torey Lovullo Odds

Lovullo promises a payout of $300 for every $100 bet.
Wild Card Series, Game 1 Lines and Updated World Series Odds 2026

Wild Card Series, Game 1 Lines and Updated World Series Odds 2026

It came down to the final day of the regular season for one team, but we now have the full Wild Card postseason picture on our plates.